Our servers run with a Red Hat Linux operating system and Red Hat, along with all other versions of Linux and BSD have case sensitive file systems.
What this means is if you created a folder named 'Blog' in your root directory, in order to access this via the web you would need to browse:
http://www.yourdomain.com/Blog
using this syntax:
http://www.yourdomain.com/blog
will not work because of the case sensitivity in the file system. In other words, the b and the B are different.
This works the same for subdomains - even if they are created in the Plesk control panel.
To avoid confusion, we recommend creating new directories in all lower case.